publications (D.K.)

  1. Nihei Y, Kitamura D. Pathogenesis of IgA nephropathy as a tissue-specific autoimmune disease. Int. Immunol. dxae047, 2024. DOI: 10.1093/intimm/dxae047.

  2. Higashiyama M, Haniuda K, Nihei Y, Kazuno S, Kikkawa M, Miura Y, Suzuki Y, Kitamura D. Oral bacteria induce IgA autoantibodies against a mesangial protein in IgA nephropathy model mice. Life Science Alliance 7(4):e202402588, 2024. DOI: 10.26508/lsa.202402588

  3. Yada Y, Matsumoto M, Inoue T, Baba A, Higuchi R, Kawai C, Yanagisawa M, Kitamura D, Ohga S, Kurosaki T, Baba Y. STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells. J. Exp. Med. 221(1):e20222178. 2024. DOI: 10.1084/jem.20222178.

  4. Thomann, A.S., McQuade, C.A., Pinjušić, K., Kolz, A., Schmitz, R., Kitamura, D., Wekerle, H., Peters, A. A B cell-driven EAE mouse model reveals the impact of B cell-derived cytokines on CNS autoimmunity. Proc. Natl. Acad. Sci. USA. 120(47): e2300733120, 2023. DOI: 10.1073/pnas.2300733120.

  5. Horiuchi S, Koike T, Takebuchi H, Hoshino K, Sasaki I, Fukuda-Ohta Y, Kaisho T and Kitamura D. SpiB regulates the expression of B-cell-related genes and increases the longevity of memory B cells. Front. Immunol. 14:1250719, 2023.
    DOI: 10.3389/fimmu.2023.1250719. 

  6. Li W, Nakano H, Fan W, Li Y, Sil P, Nakano K, Zhao F, Karmaus PW, Grimm SA, Shi M, Xu X, Mizuta R, Kitamura D, Wan Y, Fessler MB, Cook DN, Shats I, Li X, Li L. DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer. JCI insight 8 (17): e168161, 2023. DOI: 10.1172/jci.insight.168161. 

  7. Nihei Y, Higashiyama M, Miyauchi K, Haniuda K, Suzuki Y, Kubo M, Kitamura D. Subcutaneous immunization with zymosan generates mucosal IgA-eliciting memory and protects mice from heterologous influenza virus infection. Int. Immunol. 2023, DOI: 10.1093/intimm/dxad013.1.         

  8. Gokhale S, Victor E, Tsai J, Spirollari E, Matracz B, Takatsuka S, Jung J, Kitamura D, Xie P. Upregulated Expression of the IL-9 Receptor on TRAF3-Deficient B Lymphocytes Confers Ig Isotype Switching Responsiveness to IL-9 in the Presence of Antigen Receptor Engagement and IL-4. J. Immunol. 210 (8): 1059-1073, 2023. DOI: 10.4049/jimmunol.2200563.

  9.  Kato K., Haniuda, K., Fukao, S., Kitamura, D. B-cell-intrinsic DNase1L3 is essential for T-cell-independent type-II response in mice. Int. Immunol. 35 (6): 275-286, 2023. DOI: 10.1093/intimm/dxad001.

  10. Amano, S., Haniuda, K., Fukao, S., Aoki, H., Ueha, S., Kitamura, D. Commensal bacteria and the lung environment are responsible for Th2-mediated memory yielding natural IgE in MyD88-deficient mice. J. Immunol. 210 (7): 959-972, 2023. DOI: 10.4049/jimmunol.2200888. 

  11. Nihei, Y., Haniuda, K., Higashiyama, M., Asami, S., Iwasaki, H., Fukao, Y., Nakayama, M., Suzuki, H., Kikkawa, M., Kazuno, S., Miura, Y., Suzuki, Y., Kitamura, D. Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy. Science Advances 9 (12) 2023, March 22. DOI: 10.1126/sciadv.add6734.
  12. Fukushima Y, Sakamoto K, Matsuda M, Yoshikai Y, Yagita H, Kitamura D, Chihara M, Minato N, Hattori M. cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells. Cell Rep. 40: 111373, 2022. 1.     

  13. Kuhn LB, Valentin S, Stojanovic K, Strobl DC, Babushku T, Wang Y, Rambold U, Scheffler L, Grath S, John-Robbert D, Blum H, Feuchtinger A, Blutke A, Weih F, Kitamura D, Rad R, Strobl LJ, Zimber-Strobl U. RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling. Front. Immunol. 13:913275, 2022.

  14. Fu Y, Pajulas A, Wang J, Zhou B, Cannon A, Cheung CCL, Zhang J, Zhou H, Fisher AJ, Omstead DT, Khan S, Han L, Renauld JC, Paczesny S, Gao H, Liu Y, Yang L, Tighe RM, Licona-Limón P, Flavell RA, Takatsuka S, Kitamura D, Sun J, Bilgicer B, Sears CR, Yang K, Kaplan MH. Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9. Nat. Commun. 13 (1): 3811, 2022.
  15.  Fu, Y., Wang, J., Zhou, B., Pajulas, A., Gao, H., Ramdas, B., Koh, B., Ulrich, B.J., Yang, S., Kapur, R., Renauld, J.-C., Paczesny, S., Liu, Y., Tighe, R.M., Licona-Limon, P., Flavell, R.A., Takatsuka, S., Kitamura, D., Tepper, R.S., Sun, J., and Kaplan, M.H. An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment. Science Immunol. 7 (68):eabi9768, 2022. 
  16. Gao, P., Adachi, T., Okai, S., Morita, N., Kitamura, D. and Shinkura, R. Integrin CD11b provides a new marker of pre-germinal center IgA+ B cells in murine Peyer's patches. Int. Immunol. 34: 249-262, 2022.
  17. Fukao, S., Haniuda, K., Tamaki, H. and Kitamura, D. Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria. eLife 10: e72116, 2021. doi: 10.7554/eLife.72116.
  18. Kurata, M., Onishi, I., Takahara, T., Yamazaki, Y., Ishibashi, S., Goitsuka, R., Kitamura, D., Takita, J., Hayashi, Y., Largaesapda, D.A., Kitagawa, M. and Nakamura, T. C/EBPβ induces B-cell acute lymphoblastic leukemia and cooperates with BLNK mutations. Cancer Sci. 112: 4920-4930, 2021.
  19. Wigton, E.J., Mikami, Y., McMonigle, R.J., Castellanos, C.A., Wade-Vallance, A.K., Zhou, S.K., Kageyama, R., Litterman, A., Roy, S., Kitamura, D., Dykhuizen, E.C., Allen, C.D.C., Hu, H., O'Shea, J.J., Ansel, K.M. MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination. J. Exp. Med. 218 (11): e20201422, 2021. 
  20. Kitamura, D. Mechanisms for the regulation of memory B-cell recall responses in mice. Int. Immunol. 33 (12): 791-796, 2021.
  21. Haniuda, K. and Kitamura, D. Multi-faceted regulation of IgE production and humoral memory formation. Allergol. Int. 70 (2): 163-168, 2021.
  22. Wang X., Asami, S. and Kitamura D. A novel cancer immunotherapy using tumor-infiltrating B cells in the APCmin/+ mouse model. PLoS ONE 16 (1): e0245608,  2021.
  23. Haniuda, K., Fukao, S. and Kitamura, D. Metabolic reprogramming induces germinal center B cell differentiation through Bcl6 locus remodeling. Cell Rep. 33 (5):108333, 2020.
  24. Nojima, T., Reynolds, A.E., Kitamura, D., Kelsoe, G. and Kuraoka, M. Tracing self-reactive B cells in normal mice. J. Immunol. 205 (1): 90-101, 2020.
  25. Kodama, T., Hasegawa, M., Sakamoto, Y., Haniuda, K. and  Kitamura, D. Ubiquitination of IgG1 cytoplasmic tail modulates B-cell signaling and activation. Int. Immunol. 32 (6): 385-395, 2020. 
  26. Finney, J., Yang, G., Kuraoka, M., Song, S., Nojima, T., Verkoczy, L., Kitamura, D., Haynes, B.F. and Kelsoe, G. Cross-reactivity to kynureninase tolerizes B cells that express the HIV-1 broadly neutralizing antibody 2F5. J. Immunol. 203 (12): 3268-3281, 2019. 
  27. Pesch, T., Bonati, L., Kelton, W., Parola, C., Ehling, R.A., Cseprgi, L., Kitamura, D. and Reddy, S.T. Molecular design, optimization, and genomic integration of chimeric B cell receptors in murine B cells. Front. Immunol. 10: 2630, 2019.
  28. Koike. T., Harada, K., Horiuchi, S. and Kitamura, D. The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subset. eLife 8: e44245, 2019.
  29. Takatsuka, S., Yamada, H., Haniuda, K., Ichihashi, M., Chiba, J. and Kitamura, D. DNA Immunization Using in vivo Electroporation for Generating Monoclonal Antibodies Against Mouse IL-9R. Bio-protocol 9(4): e3174, 2019.
  30. Haniuda, K. and Kitamura, D. Induced Germinal Center B Cell Culture System. Bio-protocol 9(4): e3163, 2019.
  31. Litzler, L.C., Zahn, A., Meli, A.P., Hébert, S., Patenaude, A., Methot, S.P., Sprumont, A., Bois, T., Kitamura, D., Costantino, S., King, I.L., Kleinman, C.L., Richard, S. and Di Noia, J.M. PRMT5 is essential for B cell development and germinal center dynamics. Nature Commun. 10: 22, 2019.
  32. Dascani, P., Ding, C., Kong, K., Tieri, D., Hu, X., Zhang, H., Kitamura, D., Bolli, R., Rouchka, E.C. and Yan, J. Transcription Factor STAT3 Serves as a Negative Regulator Controlling IgE Class Switching in Mice. ImmunoHorizons 2 (11): 349-362, 2018.
  33. Takatsuka, S., Yamada, H., Haniuda, K., Saruwatari, H., Ichihashi, M., Renauld, J.-C. and Kitamura, D. IL-9 receptor signaling in memory B cells regulates humoral recall responses. Nature Immunol. 19 (9): 1025-1034, 2018.
  34.  Le Gallou, S., Zhou, Z., Thai, L.H., Fritzen, R., de Los Aires, A.V., Mégret, J., Yu, P., Kitamura, D., Bille, E., Tros, F., Nassif, X., Charbit, A., Weller, S., Weill, J.C. and Reynaud, C.A. A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses. J. Exp. Med. 215 (8): 2035-2053, 2018.
  35. Li, X., Gadzinsky, A., Gong, L., Tong, H., Calderon, V., Li, Y., Kitamura, D., Klein, U., Langdon, W.Y., Hou, F., Zou, Y.R. and Gu, H. Cbl ubiquitin ligases control B cell exit from the germinal-center reaction. Immunity 48 (3): 530-541, 2018.
  36. Jiménez-Alcázar, M., Rangaswamy, C., Panda, R., Bitterling, J., Simsek, Y.J., Long, A.T., Bilyy, R., Krenn,V., Renné, C., Renné, T., Kluge, S., Panzer, U. Mizuta, R., Mannherz, H.G., Kitamura, D., Herrmann, M., Napirei, M. and Fuchs, T.A. Host DNases prevent vascular occlusion by neutrophil extracellular traps. Science 358 (6367): 1202-1206, 2017.
  37. Le Gallou, S., Nojima, T., Kitamura, D., Weill, J.C. and Reynaud, C.A. The AID-Cre-ERT2 model: A tool for monitoring B cell immune responses and generating selective hybridomas. Methods Mol. Biol. 1623: 243-251, 2017.
  38. Haniuda, K., Nojima, T. and Kitamura, D. In vitro-induced germinal center B cell culture system. Methods Mol. Biol. 1623: 125-133, 2017.
  39. Kuraoka, M., Snowden, P.B., Nojima, T., Verkoczy, L., Haynes, B.F., Kitamura, D. and Kelsoe, G. BCR and endosomal TLR signals synergize to increase AID expression and establish central B cell tolerance. Cell Rep. 18(7):1627-1635, 2017. 
  40. Lee, P., Zhu, Z., Hachmann, J., Nojima, T., Kitamura, D., Salvesen, G. and Rickert, R.C. Differing requirements for MALT1 function in peripheral B cell survival and differentiation. J. Immunol. 198: 1066-1080, 2017.
  41. Koyama, R., Arai, T., Kijima, M., Sato, S., Miura, S., Yuasa, M., Kitamura, D., Mizuta, R. DNase γ, DNase I and caspase-activated DNase cooperate to degrade dead cells. Genes Cells 21: 1150-1163, 2016.
  42. Kei Haniuda, Saori Fukao, Tadahiro Kodama, Hitoshi Hasegawa, Daisuke Kitamura. Autonomous membrane IgE signaling prevents IgE-memory formation. Nature Immunol. 17: 1109-1117, 2016.
  43. Domeier, P.P., Chodisetti, S.B., Soni, C., Schell, S.L., Elias, M.J., Wong, E.B., Cooper, T.K., Kitamura, D. and Rahman, Z.S. IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J. Exp. Med. 213 (5): 715-732, 2016.
  44. Kuraoka, M., Schmidt, A.G., Nojima, T., Feng, F., Watanabe, A., Kitamura, D., Harrison, S.C., Kepler, T.B. and Kelsoe, G. Complex Antigens Drive Permissive Clonal Selection in Germinal Centers. Immunity 44: 542-552, 2016.
  45. Webb, L.M., Datta, P., Bell, S.E., Kitamura, D., Turner, M. and Butcher, G.W. GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo. J. Immunol. 196: 207-216, 2016.
  46. Purwada, A., Jaiswal, M.K., Ahn, H., Nojima, T., Kitamura, D., Gaharwar, A.K., Cerchietti, L. and Singh, A. Ex vivo engineered immune organoids for controlled germinal center reactions. Biomaterials 63: 24-34, 2015.
  47. Kitabatake, M., Soma, M., Zhang, T., Kuwahara, K., Fukushima, Y., Nojima, T., Kitamura, D. and Sakaguchi, N. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. J. Immunol. 194(4):1480-1488, 2015.
  48. Wu, L., Parekh, V.V., Hsiao, J., Kitamura, D. and Van Kaer, L. Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance. Proc. Natl. Acad. Sci. USA 111 (43): E4638-E4647, 2014.
  49. Arai, T., Koyama, R., Yuasa, M., Kitamura, D., Mizuta, R. Acrolein, a highly toxic aldehyde generated under oxidative stress in vivo, aggravates the mouse liver damage after acetaminophen overdose. Biomedical Research 35 (6): 389-395, 2014. 
  50. Fukao, S., Haniuda, K., Nojima, T., Takai, T. and Kitamura, D. Gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells. J. Immunol. 193 (2): 635-644, 2014.
  51. Moutai, T., Yamana, H., Nojima, T. and Kitamura, D. A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro. PLoS One 9 (3): e92732, 2014.
  52. Mizuta R, Araki S, Furukawa M, Furukawa Y, Ebara S, Shiokawa D, Hayashi K, Tanuma S, Kitamura D. DNase γ Is the Effector Endonuclease for Internucleosomal DNA Fragmentation in Necrosis. PLoS One 8: e80223, 2013.
  53. Caganova, M., Carrisi, C., Varano, G., Mainoldi, F., Zanardi, F., Germain, P.L., George, L., Alberghini, F., Ferrarini, L., Talukder, A.K., Ponzoni, M., Testa, G., Nojima, T., Doglioni, C., Kitamura, D., Toellner, K.M., Su, I.H., Casola, S. Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis. J. Clin. Invest. 123: 5009-5022, 2013.
  54. Hidano, S., Kitamura, D., Kumar, L., Geha, R.S. and Goitsuka, R.: SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils. Int. Immunol. 24:719-727, 2012.
  55. Kawano, Y., Ouchida, R., Wang, J.Y., Yoshikawa, S., Yamamoto, M., Kitamura, D. and Karasuyama, H. A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosomal-associated protein transmembrane 5. Mol. Cell. Biol. 32 (21): 4462-4471, 2012.
  56. Ozaki, N., Suzuki, S., Ishida, M., Harada, Y., Tanaka, K.,Sato, Y., Kono, T., Kubo, M., Kitamura, D., Encinas, J., Hara, H. and Yoshida, H.: Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis. Int. Immunol. 24: 539-550, 2012.
  57. Sakamoto, S., Wakae, K., Anzai, Y., Murai, K., Tamaki, N., Miyazaki, M., Miyazaki, K., Romanow, W. J., Ikawa, T., Kitamura, D., Yanagihara, I., Minato, N., Murre, C. and Agata, Y.: E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin k locus. J. Immunol. 188:5547-5560, 2012.
  58. Miyazaki, A., Yogosawa, S., Murakami, A. and Kitamura, D.: Identification of CMTM7 as a Transmembrane Linker of BLNK and the B-cell Receptor. PLoS One 7 (2): e31829, 2012.
  59. Nojima, T., Haniuda, K., Moutai, T., Matsudaira, M., Mizokawa, S., Shiratori, I., Azuma, T. and Kitamura, D.: In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo. Nat. Commun. 2:465, 2011.
  60. Haniuda, K., Nojima, T., Ohyama, K. and Kitamura, D.: Tolerance induction of IgG+ memory B cells by T-cell independent type II antigens. J. Immunol. 186: 5620-5628, 2011.
  61. Furukawa, Y., Hayashi, T., Mizuta. M,, Ebara, S., Kiku, Y., Ozawa, T., Matsubara, T., Ito, I., Kitamura, D. and Mizuta, R.: Increased concentration of high-mobility group box 1 protein in milk is related to the severity of bovine mastitis. Vet. Res. Commun. 35(1): 47-54. 2011.
  62. Scielzo, C., Bertilaccio, M.T, Simonetti, G., Dagklis, A., Ten Hacken, E., Fazi, C., Muzio, M., Caiolfa, V., Kitamura, D., Restuccia, U., Bachi, A., Rocchi, M., Ponzoni, M., Ghia, P. and Caligaris-Cappio, F.: HS1 has a central role in the trafficking and homing of leukemic B cells. Blood 116 (18): 3537-3546, 2010.
  63. Kim, B.-H., Jee, J.-G., Yin, C.-H., Sandoval, C., Jayabose, S., Kitamura, D., Bach, E. A., Baeg, G.-H.: NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3. Mol. Cancer 9:36, 2010.
  64. Mizuta, R., Mizuta, M., Araki, S., Suzuki, K., Ebara, S., Furukawa, Y., Shiokawa, D., Tanuma, S. and Kitamura, D. DNase γ-dependent and -independent apoptotic DNA fragmentations in Ramos Burkitt's lymphoma cell line. Biomed. Res. 30 (3): 165-170, 2009.
  65. Okamoto, N., Okamoto, M., Araki, S., Arakawa, H., Mizuta, R. and Kitamura, D. Possible contribution of DNase γ to immunoglobulin V gene diversification. Immunol. Lett. 125 (1): 22-30, 2009.
  66. Imamura, Y., Oda, A., Katahira, T., Bundo, K., Pike, K.A., Ratcliffe, M.J.H. and Kitamura, D. BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation. J. Biol. Chem. 284 (15): 9804-9813, 2009
  67. Nakayama, J., Yamamoto, M., Hayashi, K., Satoh, H., Bundo, K., Kubo, M., Goitsuka, R., Farrar, M. A. and Kitamura D. BLNK suppresses pre-B cell leukemogenesis through inhibition of JAK3. Blood 113 (7): 1483-1492, 2009
  68. Kahner, B. N., Dorsam, R. T., Kim, S., Shankar, H., Kitamura, D., Kunapuli, S. P. Hematopoietic lineage cell-specific protein-1 (HS1) regulates PAR-mediated ERK activation and thromboxane generation in platelets. Platelets 19 (8): 614-623, 2008.
  69. Oda, A., Ono, T., Yamamoto, M., Goitsuka, R. and Kitamura, D. PKCη directs induction of IRF-4 expression and Ig κ gene rearrangement in pre-BCR signaling pathway. Int. Immunol. 20 (11): 1417-1426, 2008.
  70. Shinohara, M., Koga, T., Okamoto, K., Sakaguchi, S., Arai, K., Yasuda, H., Takai, T., Kodama, T., Morio, T,. Geha, R. S., Kitamura, D., Kurosaki, T., Ellmeier, W. and Takayanagi, H. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell 132 (5): 794-806, 2008. 
  71. Hidano, S., Sasanuma, H., Ohshima, K., Seino, K.-I., Kumar, L., Hayashi, K., Hikida, M., Kurosaki, T., Taniguchi, M., Geha, R. S., Kitamura, D. and Goitsuka, R. Distinct regulatory functions of SLP-76 and MIST in NK cell cytotoxicity and IFN-γ production. Int. Immunol. 20 (3): 345-352, 2008.
  72. Kitamura, D. Self-nonself recognition through B-cell antigen receptor. In How the Immune System Recognizes Self and Nonself: Immunoreceptors and Their Signaling, D. Kitamura, ed. (Springer), November 2007.
  73. Goitsuka, R., Chen, C.L., Benyon, L., Asano, Y., Kitamura, D. and Cooper, M.D. Chicken cathelicidin-B1, an antimicrobial guardian at the mucosal M cell gateway. Proc. Natl. Acad. Sci. USA 104(38): 15063-15068, 2007
  74. Kahner, B. N., Dorsam, R. T., Mada, S. R., Kim, S., Stalker, T. J., Brass, L. F., Daniel, J. L., Kitamura, D. and Kunapuli, S. P. Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation. Blood 110(7): 2449-2456, 2007.
  75. Shiokawa, D., Shika, Y., Araki, S., Sunaga, S., Mizuta, R., Kitamura, D. and Tanuma, S.　Stage-specific expression of DNase gamma during B-cell development and its role in B-cell receptor-mediated apoptosis in WEHI-231 cells. Cell Death Differ. 14 (5):992-1000, 2007.
  76. Mizuta, R., Mizuta, M., Araki, S., Shiokawa, D., Tanuma, S.-I. and Kitamura, D.: Action of apoptotic endonuclease DNase gamma on naked DNA and chromatin substrates. Biochem. Biophys. Res. Commun. 345(2):560-567, 2006.
  77. Yamamoto, M., Hayashi, K., Nojima, T., Matsuzaki, Y., Kawano, Y., Karasuyama, H., Goitsuka, R. and Kitamura, D.: BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces κ gene rearrangement. Blood 108 (8):2703-2711, 2006.
  78. Fujiwara, N., Hidano, S., Mamada, H., Ogasawara, K., Kitamura, D., Cooper, M.D., Hozumi, N., Chen, C.-l. and Goitsuka, R.: A novel avian homologue of CD72, chB1r, down modulates BCR-mediated activation signals. Int. Immunol. 18(5):775-783, 2006.
  79. Sasanuma, H., Tatsuno, A., Hidano, S., Ohshima, K., Matsuzaki, Y., Hayashi, K., Lowell, C. A., Kitamura, D. and Goitsuka, R.: Dual function for the adaptor MIST in IFN-γ production by NK and CD4+NKT cells regulated by the Src-kinase Fgr. Blood 107(9):3647-3655, 2006.
  80. Nojima, T., Hayashi, K., Goitsuka, R., Nakayama, K., Nakayama, K.-i. and Kitamura, D.: Double knockout mice show BASH and PKCd have different epistatic relationships in B cell maturation and CD40-mediated activation. Immunol. Lett.105(1):48-54, 2006.
  81. Katahira, T., Imamura, Y. and Kitamura, D.: The BASH/BLNK/SLP-65-associated protein BNAS1 regulates antigen-receptor signal transmission in B cells. Int. Immunol. 18 (4):545-553, 2006.
  82. Mizuta R., Mizuta, M. and Kitamura, D.: Guanine is indispensable for immunoglobulin switch region RNA-DNA hybrid formation. J. Electron Microsc. 54 (4):403-408, 2005.
  83. Nishida, K., Yamasaki, S., Ito, Y., Kabu, K., Hattori, K., Tezuka, T., Nishizumi, H., Kitamura, D., Goitsuka, R., Geha, R. S., Yamamoto, T., Yagi, T., Hirano, T.: FcεRI-mediated mast cell degradation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J. Cell. Biol. 170 (1): 115-126, 2005.
  84. Okamoto, M., Okamoto, N., Yashiro, H., Shiokawa, D., Sunaga, S., Yoshimori, A., Tanuma, S. and Kitamura, D.: Involvement of DNase γ in the resected double-strand DNA breaks in immunoglobulin genes. Biochem. Biophys. Res. Commun. 327: 76-83, 2005.
  85. Hayashi, K., Nojima, T., Goitsuka, R., Kitamura, D.: Impaired receptor editing in the primary B cell repertoire of BASH-deficient mice. J. Immunol. 173 (10): 5980-5988, 2004.
  86. Sasanuma, H., Tatsuno, A., Tsuji, K., Hidano, S., Morita, S., Kitamura, T., Kubo, M., Kitamura, D. and Goitsuka, R.: Transcriptional regulation of SLP-76 family hematopoietic cell adaptor MIST/Clnk by STAT5. Biochem. Biophys. Res. Commun. 321(1):145-153, 2004.
  87. Yamamoto, M., Nojima, T., Hayashi, K., Goitsuka, R., Furukawa, K., Azuma, T. and Kitamura, D.: BASH-deficient mice: Limited primary repertoire and antibody formation, but sufficient affinity maturation and memory B cell generation, in anti-NP response. Int. Immunol. 16 (8):1161-1171, 2004.
  88. Imamura Y., Katahira, T. and Kitamura, D.: Identification and Characterization of a Novel BASH N-terminus Associated Protein, BNAS2. J. Biol. Chem. 279 (25): 26425-26432, 2004.
  89. Chen, M., Mun, H. S., Piao, L. X., Aosai, F., Norose, K., Mohamed, R. M., Belal, U. S., Fang, H., Ahmed, A. K., Kang, H. K., Matsuzaki, G., Kitamura, D., Yano, A.: Induction of protective immunity by primed B-1 cells in Toxoplasma gondii -infected B cell-deficient mice. Microbiol. Immunol. 47 (12): 997-1003, 2003.
  90. Mizuta R., Mizuta, M. and Kitamura, D.: Atomic force microscopy analysis of rolling circle amplification of plasmid DNA. Arch. Histol. Cytol. 66 (2):175-181, 2003.
  91. Johmura, S., Oh-hora, M., Inabe, K., Nishikawa, Y., Hayashi, K., Vigorito, E., Kitamura, D., Turner, M., Shingu, K., Hikida, M. and Kurosaki, T.: Regulation of Vav Localization in Membrane Rafts by Adaptor Molecules Grb2 and BLNK. Immunity 18 (6): 777-787, 2003.
  92. Hayashi, K., Yamamoto M., Nojima, T., Goitsuka, R. and Kitamura, D.: Distinct signaling requirements for Dμ selection, IgH allelic exclusion, pre-B cell transition and tumor suppression in B-cell progenitors. Immunity 18 (6): 825-836, 2003.
  93. Fujii, Y., Wakahara, S., Nakao, T., Hara, T., Ohtake, H., Komurasaki, T., Kitamura, K., Tatsuno, A., Fujiwara, N., Hozumi, N., Ra, C., Kitamura, D., Goitsuka, R.: Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. FEBS Lett. 540:111-116, 2003.
  94. Mizuta, R., Iwai, K., Shigeno, M., Mizuta, M., Uemura, T., Ushiki, T., Kitamura, D.: Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope. J. Biol. Chem. 278, 4431-4434, 2003.
  95. Mizuta, R., Mizuta, M., Araki, S. and Kitamura, D.: RAG2 is down-regulated by cytoplasmic sequestration and ubiquitin-dependent degradation. J. Biol. Chem. 277 (44): 41423-41427, 2002.
  96. Hayashi, K., Kobayashi, T., Umino T., Goitsuka, R., Matsui, Y. and Kitamura, D.: SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast. Mech. Dev. 118: 99-109, 2002.
  97. Goitsuka, R., Tatsuno, A., Ishiai, M., Kurosaki, T. and Kitamura, D.: MIST functions through distinct domains in immunoreceptor signaling in the presence and absence of LAT. J. Biol. Chem. 276(38): 36043-36050, 2001.
  98. Tsuji, S., Okamoto, M., Yamada, K., Okamoto, N., Goitsuka, R., Arnold, R., Kiefer, F. and Kitamura, D.: B cell adaptor containing Src Homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase1. J. Exp. Med. 194: 529-539. 2001.
  99. Goitsuka, R., Mamada, H., Kitamura, D., Cooper, M. D. and Chen, C. H.: Genomic structure and transcriptional regulation of the early B-cell gene chB1. J. Immunol. 167(3):1454-1460. 2001.
  100. Terauchi, A., Hayashi, K., Kitamura, D., Azuma, T.: A pivotal role for DNaseI-sensitive regions 3b and/or 4 in the induction of somatic hypermutation of IgH genes. J. Immunol. 167(2):811-820. 2001.
  101. Morimura, T., Miyatani, S., Kitamura, D. and Goitsuka, R.: Notch signaling suppresses IgH gene expression in chicken B cells: implication in spatially restricted expression of Serrate2/Notch1 in the bursa of Fabricius. J. Immunol. 166(5):3277-3283. 2001.
  102. Morimura, T., Goitsuka, R., Zhang, Y., Saito, I., Reth, M. and Kitamura, D.: Cell cycle arrest and apoptosis induced by Notch1 in B cells. J. Biol. Chem. 275: 36523-36531, 2000.
  103. Fusaki, N., Tomita, S., Wu., Y., Okamoto, N., Goitsuka, R., Kitamura, D. and Hozumi, N.: BLNK is associated with the CD72/SHP-1/Grb2 complex in the WEHI231 cell line after membrane IgM cross-linking. Eur. J. Immunol. 30:1326-1330, 2000.
  104. Goitsuka, R., Kanazashi, H., Sasanuma, H., Fujimura, Y., Hidaka, Y., Tatsuno, A., Ra, C., Hayashi, K. and Kitamura, D.: A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation. Int. Immunol. 12:573-580, 2000.
  105. Hayashi, K., Nittono, R., Okamoto, N., Tsuji, S., Hara, Y., Goitsuka, R. and Kitamura, D.: The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells. Proc. Natl. Acad. Sci. USA 97:2755-2760,　 2000.
  106. Nagafuchi, S., Katsuta, H., Kogawa, K., Akashi, T., Kondo, S., Sakai, Y., Tsukiyama, T., Kitamura, D., Niho, Y. and Watanabe, T.: Establishment of an embryonic stem (ES) cell line derived from a non-obese diabetic (NOD) mouse: in vivo differentiation into lymphocytes and potential for germ line transmission. FEBS Lett. 455:101-104, 1999.
  107. Goitsuka, R., Fujimura, Y., Mamada, H., Umeda, A., Morimura, T., Uetsuka, K., Doi, K.,Tsuji, S. and Kitamura, D.: BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius. J. Immunol. 161:5804-5808, 1998.
  108. Akashi, T., Nagafuchi, S., Anzai, K., Kitamura, D., Wang, J., Taniuchi, I., Niho, Y. and Watanabe, T.: Proliferation of CD3+ B220- single-positive normal T cells was suppressed in B-cell-deficient lpr mice. Immunology 93:238-248, 1998.
  109. Lin, Q., Taniuchi, I., Kitamura, D., Wang, J., Kearney, J. F., Watanabe, T. and Cooper, M. D.: T and B cell development in BP-1/6C3/aminopeptidase A-deficient mice. J. Immunol. 160:4681-4687, 1998.
  110. Yamamoto, A., Takagi, H., Kitamura, D., Tatsuoka, H., Nakano, H., Kawano, H., Kuroyanagi, H., Yahagi, Y., Kobayashi, S., Koizumi, K., Sakai, T., Saito, K., Chiba, T., Kawamura, K., Suzuki, K., Watanabe, T., Mori, H. and Shirasawa, T.: Deficiency in protein L-isoaspartyl methyltransferase results in a fatal progressive epilepsy. J Neurosci. 18:2063-2074, 1998.
  111. Katsuta, H., Tsuji, S., Niho, Y., Kurosaki, T. and Kitamura, D.: Lyn-mediated down-regulation of B-cell antigen receptor signaling: inhibition of protein kinase C activation by Lyn in a kinase-independent fashion. J. Immunol. 160:1547-1551, 1998.
  112. Akashi, T., Nagafuchi, S., Anzai, K., Kondo, S., Kitamura, D., Wakana, S., Ono, J., Kikuchi, M., Niho, Y. and Watanabe, T.: Direct evidence for the contribution of B cells to the progression of insulitis and the development of diabetes in non-obese diabetic mice. Int. Immunol. 9: 1159-1164, 1997.
  113. Yamanashi, Y., Fukuda, T., Nishizumi, H., Inazu, T., Higashi, K., Kitamura, D., Ishida, T., Yamamura, H., Watanabe, T. and Yamamoto, T.: Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis. J. Exp. Med. 185: 1387-1392, 1997.
  114. Suzuki Y., Demoliere C., Kitamura D., Takeshita H., Deuschle U. and Watanabe T.: HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. J. Immunol. 158: 2736-2744, 1997.
  115. Inoue, I., Yanai, K., Kitamura, D., Taniuchi, I., Kobayashi, T., Niimura, K., Watanabe, T. and Watanabe, T.: Impaired locomotor activity and exploratory behaviour in mice lacking histamine H1 receptors. Proc. Natl. Acad. Sci. USA 93: 13316-13320, 1996.
  116. Inoue, I., Taniuchi, I., Kitamura, D., Jenkins, N. A., Gilbert, D. J., Copeland, N. G. and Watanabe, T.: Characteristics of the mouse genomic histamine H1 receptor gene. Genomics 36: 178-181, 1996.
  117. Brundler, M.-A., Aichele, P., Bachmann, M., Kitamura, D., Rajewsky, K. and Zinkernagel, R. M.: Immunity to viruses in B cell-deficient mice: influence of antibodies on virus persistence and on T cell memory. Eur. J. Immunol. 26: 2257-2262, 1996.
  118. Kawagoe, K., Kitamura, D., Okabe, M., Taniuchi, I., Ikawa, M., Watanabe, T., Kinoshita, T. and Takeda, J.:Glycosylphosphatidylinositol-anchor-deficient mice: Implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria. Blood 87: 3600-3606, 1996.
  119. Egashira,　 M., Kitamura, D., Watanabe, T. and Niikawa, N.:The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization. Cytogenet. Cell Genet. 72: 175-176, 1996.
  120. Nishizumi, H., Taniuchi, I., Yamanashi, Y., Kitamura, D., Ilic, D., Mori, S., Watanabe, T. and Yamamoto, T.:Impaired proliferation of peripheral B cell and indication of autoimmune disease in lyn-deficient mice. Immunity 3: 549-560, 1995.
  121. Zeng, H., Yoshida, T., Kurosaki, T., Yamamura, H., Oshima, A., Kitamura, D., Watanabe, T and Morikawa, M.:Phosphorylation of HS1, GAP- associated p190 and a novel GAP- associated p60 protein by Cross-linking of FcγRIIIA. J. Biochem. 118: 1166-1174, 1995.
  122. Taniuchi, I., Kitamura, D., Maekawa, Y., Fukuda, T., Kishi, H. and Watanabe, T.: Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases. EMBO J. 14: 3664-3678, 1995.
  123. Fukuda, T., Kitamura, D., Taniuchi, I., Maekawa, Y., Benhamou, L. E., Sarthou, P. and Watanabe, T.: Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate. Proc. Natl. Acad. Sci. USA 92: 7302-7306, 1995.
  124. Kitamura, D., Kaneko, H., Taniuchi, I., Akagi, K., Yamamura, K. and Watanabe, T.: Molecular cloning and characterization of mouse HS1. Biochem. Biophys. Res. Commun. 208: 1137 - 1146, 1995.
  125. Sato, S., Katagiri, T., Takaki, S., Kikuchi, Y., Hitoshi, Y., Yonehara, S., Tsukada, S., Kitamura, D., Watanabe, T., Witte, O. and Takatsu, K.: IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases. J. Exp. Med. 180: 2101-2111, 1994.
  126. Benhamou, L. E., Watanabe, T., Kitamura, D., Cazenave, P.-A. and Sarthou, P.: Signaling properties of anti-immunoglobulin resistant variants of WEHI-231 B lymphoma cells. Eur. J. Immunol. 24: 1993-1999, 1994.
  127. Beutner, U., Kraus, E., Kitamura, D., Rajewsky, K. and Huber, B.T.: B cells are essential for Murine Mammary Tumor Virus transmission, but not for presentation of endogenous superantigens. J. Exp. Med. 179: 1457-1466, 1994.
  128. von der Weid T., Kitamura D., Rajewsky K. and Langhorne J.: A dual role for B cells in Plasmodium chabaudi chabaudi (AS) infection? Res. Immunol. 145: 412-419, 1994.
  129. Wagner, S.D., Williams, G.T., Larson, T., Neuberger, M.S., Kitamura, D., Rajewsky, K., Xian, J. and Bruggemann, M.: Antibodies generated from human immunoglobulin miniloci in transgenic mice. Nucl. Acids Res. 22: 1389-1393, 1994.
  130. Ohno, H., Aoe, T., Taki, S., Kitamura, D., Ishida, Y., Rajewsky, K. and Saito, T.: Developmental and functional impairment of T cells in mice lacking CD3ζ chains. EMBO J. 12: 4357-4366, 1993.
  131. Takeda, S., Zou, Y-R., Bluethmann, H., Kitamura, D., Muller U. and Rajewsky, K.: Deletion of the immunoglobulin κ chain intron enhancer abolishes κ chain gene rearrangement in cis but not λ chain gene rearrangement in trans. EMBO J. 12: 2329-2336, 1993.
  132. Yamanashi, Y., Okada, M., Semba, T., Yamori, T., Umemori, H., Tsunasawa, S., Toyoshima, K., Kitamura, D., Watanabe, T. and Yamamoto, T.: Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling. Proc. Natl. Acad. Sci. USA 90: 3631-3635, 1993.
  133. Ehlich, A., Schaal, S., Gu, H., Kitamura, D., Muller, W. and Rajewsky, K.: Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72: 695-704, 1993.
  134. Kitamura, D., Kudo, A., Schaal, S., Muller, W., Melchers, F. and Rajewsky, K.: A critical role of λ5 protein in B cell development. Cell 69, 823-831, 1992.
  135. Rajewsky, K., Ehlich, A., Muller, W., Taki, S. and Kitamura, D.: Allelic exclusion model questioned - Reply. Nature 359, 371-372, 1992.
  136. Kitamura, D. and Rajewsky, K.: Targeted disruption of m chain membrane exon causes loss of heavy chain allelic exclusion. Nature 356, 154-156, 1992.
  137. Gu, H., Kitamura, D. and Rajewsky, K.: DH reading frame bias: evolutionary selection, antigen selection or both? Evolutionary selection. Immunol. Today 12, 420-421, 1991.
  138. Kitamura, D., Roes, J., Kuhn, R. and Rajewsky, K.: A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350, 423-426, 1991.
  139. Gu, H., Kitamura, D. and Rajewsky, K.: B cell development regulated by gene rearrangement: Arrest of maturation by membrane-bound Dμ protein and selection of DH element reading frames. Cell 65, 47-54, 1991.
  140. Kitamura, D., Kaneko, H., Miyagoe, Y., Ariyasu, T. and Watanabe, T.: Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage. Nucl. Acids Res. 17, 9367-9379, 1989.
  141. Araki, K., Maeda, H., Wang, J., Kitamura, D. and Watanabe, T.: Purification of a nuclear trans-acting factor involved in the regulated transcription of a human immunoglobulin heavy chain gene. Cell 53, 723-730, 1988.
  142. Wang, J., Nishiyama, K., Araki, K., Kitamura, D. and Watanabe, T.: Purification of an octamer sequence (ATGCAAAT) -binding protein from human B cells. Nucl. Acids Res. 15, 10105-10116, 1987.
  143. Kitamura, D., Maeda, H., Araki, K., Kudo, A. and Watanabe, T.: Regulation of immunoglobulin gene transcription by labile repressor factor(s). Eur. J. Immunol. 17, 1249-1256, 1987.
  144. Motomura, M., Kitamura, D., Araki, K., Maeda, H., Kudo, A. and Watanabe, T.: The cis-acting regulatory elements of immunoglobulin heavy chain gene involved in enhanced immunoglobulin production after lipopolysaccharide (LPS) stimulation. Mol. Immunol. 24, 759-764, 1987.
  145. Maeda, H., Araki, K., Kitamura, D., Wang, J. and Watanabe, T.: Nuclear factors binding to the human immunoglobulin heavy-chain gene enhancer. Nucl. Acids Res. 15, 2851-2869, 1987.
  146. Maeda, H., Kitamura, D., Kudo, A., Araki, K. and Watanabe, T.: Trans-acting nuclear protein responsible for induction of rearranged human immunoglobulin heavy chain gene. Cell 45, 25-33, 1986.
  147. Watanabe, T., Maeda, H., Kudo, A., Ishihara, T., Ohara, J., Eda, Y. and Kitamura, D.: Microinjection of cytoplasmic and nuclear factors into cells of the immune system: a new technique and its application in immunology. Lymphokines 12, 239-257, 1985.

東京理科大学 生命医科学研究所 

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